Approximately 10 percent of U women...

Approximately 10 percent of U women 15 to 19 years of age use depository medroxyprogesterone (DMPA; Depo-Provera) for contraception. late studies have shown that DMPA has an adverse impact upon bone mineral density. This is of particular transaction in young women because peak bone mass is bring to maturityed at this age. Any negative impact upon peak bone mass at this time could outcome in increased bone fracture risk later in life. Studies have shown that bone density los meet the eyes in young women who use DMPA, nevertheless one study found a significant gain in bone mineral density after discontinuation of DMPA. Schole and associates guidanceed a population-based prospective cohort studious mood to evaluate bone mineral density changes in young women during and after use of DMPA.

The trial participants were adolescents 14 to 18 years of age. sum of two units groups were recruited for the study; the collections consisted of those who were using DMPA for contraception and those who were not. The participants were evaluated at baseline and each six months for at least 24 month The evaluation included questionnaires covering health history, pregnancy history, contraception, smoking, physical activity, alcohol use, caffeine intake, demographic details, and food-intake common occurrence for the preceding 30 days. The participants' height, weight, and bone mineral density of the hip, spine, and whole carcass also were assessed. The main result measure was the change in bone mineral density during the research period.

Eighty young women in the DMPA assign places to and 90 in the comparison arrange were included in the final analysis. Of the women in the DMPA assemblage 61 stopped using it during the follow-up period. The young women who used DMPA had a significant decrease in their bone mineral density at the hip and spine compared with those who did not use DMPA. There was no significant difference in whole-body bone mineral density measurements between the form into groupss Participants who had not used DMPA previously had a significant los of bone mineral density compared with those with a history of DMPA use. The young women who discontinued DMPA use during the studious mood had a significantly increased bone mineral density at all three sites compared with the repress group.

The authors judge that DMPA use in young women causes significant bone mineral density los at the hip and spine. They also note that there are significant gains in bone mineral density when DMPA is discontinued, suggesting that the bone mass los is reversible.

KARL E MILLER, MD

Schole D et al. Change in bone mineral density among adolescent women using and discontinuing station-house medroxyprogesterone acetate contraception. Arch Pediatr Adolesc M February 2005;159:139-44

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