Anorexia nervosa affects 02 to 4 pe...

Anorexia nervosa affects 02 to 4 percent of adolescent girls in the United States and is increasing in prevalence. In addition to the 56 percent mortality rate of adults with anorexia, changes in bone metabolism and other nutritional parameters are customary Few data exist to define the inferences of these complications. Misra and colleagues studied various hemodynamic and laboratory parameters that are construct in community-dwelling adolescents with anorexia to dignify vigilance as well as timely and effective intervention.

The inquiry included 118 adolescent girls 12 to 19 years of age. Sixty girls diagnosed with anorexia nervosa were compared with 58 healthy girls. Participants in the anorexia nervosa form into groups were receiving outpatient care still had not been hospitalized for at least three month The authors evaluated clinical characteristics (eg material substance mass index [BMI], blood influence heart rate, blood count, bone age, chronologic age, and bone density) as well as biochemical data (eg follicle-stimulating hormone, luteinizing hormone, hematocrit, grape-sugar potassium, calcium, creatinine, estradiol [Estraderm], urinary unrestrained cortisol, and insulin-like growth factor 1 [IGF-1] levels) BMI and weight were lower in the anorexia nervosa cluster compared with the control assemblage as was the ratio of bone age and chronologic age. Premenarchal girls with anorexia nervosa were older than premenarchal girls in the direction group. The anorexia nervosa cluster also had lower blood press and mean heart rates than girls in the restrain group. Participants with anorexia nervosa were more likely to have a higher mean corpuscular bulk and lower red and white children cell counts, despite insignificant differences in hematocrits. Calcium and phosphorus flats were not different between clusters but potassium and urinary at liberty cortisol levels were slightly higher in the anorexia nervosa assemblage Urinary free cortisol levels standardized for creatinine and for surface area and creatinine were also higher in the anorexia nervosa cluster compared to the control dispose Estradiol and IGF-1 levels were significantly lower in the anorexia nervosa assign places to Participants in the anorexia nervosa assemblage had significantly lower bone density, particularly at the lumbar spine. Bone density measurements at the hip and femoral neck were also significantly lower in the anorexia nervosa cluster When controlling for other factors, lean material part mass was the most significant predictor of bone mineral density at principally sites.

The authors terminate that community-dwelling adolescent girls with anorexia nervosa had an increased risk for hematologic, metabolic, hemodynamic, and skeletal abnormalities, including bradycardia, depressed blood pressure, and pubertal delay, compared with healthy girls. They make acceptable that physicians monitor these parameters closely in anorexia nervosa patients.

CAROLINE WELLBERY, MD

Misra M et al. drifts of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls. Pediatrics December 2004;114:1574-83

COPYRIGHT 2005 American Academy of Family Physicians

COPYRIGHT 2005 Gale Group