Los of bone mineral density in wome...

Los of bone mineral density in women using station medroxyprogesterone acetate for contraception has been reported in several small, short-term studies. Berenson and colleagues deportment ed a controlled trial to compare the general intent of oral and depot contraception forward bone mineral density over at least sum of two units years.

They studied women 18 to 33 years of age who sought contraception and could encounter the minimum criteria for hall into the armed forces. Women wishing to receive hormonal contraception chosened either injectable or oral forms. Injectable contraception was provided as 150 mg of warehouse medroxyprogesterone acetate every three month Women selecting oral contraception were randomly assigned to 0035 mg of ethinyl estradiol plus 10 mg of norethindrone or 0030 mg of ethinyl estradiol plus 015 mg desogestrel Women who did not wish to use hormonal contraception acted as manage subjects. Researchers gathered base-line data upon medical history, demographic variables, smoking status, carcass mass index, exercise habits, and calcium intake. Bone mineral density at the lumbar spine was assessed at baseline and after common and two years of contraceptive use.

Data were entire in 110 women, and at least individual follow-up bone mineral density touchstone result was available in 191 women At baseline, the four form into groupss were similar in all important variables exclude that smoking was significantly les general in women using oral contraceptives. After controlling for significant variables, women using depository medroxyprogesterone acetate for two years experienced an average los from baseline of 57 percent in spinal bone mineral density. Women using the desogestrel oral contraceptive had a los of approximately 20 per-cent between the first and next to the first year, but this loss was not statistically significant through the two years. Women using norethindrone showed no significant change in bone mineral density above the two years. Women in the ascendency group had a gain of 26 percent in bone mineral density during the other year of the study.

The authors terminate that women using depot medroxyprogesterone acetate contraception wasted approximately 3 percent in bone mineral density by year. Because this form of contraception is intended for long-term use, they call for additional studies to determine if the los continues linearly and to identify strategies to counteract the effect

ANNE D WALLING, MD

Berenson AB, et al. events of hormonal contraception on bone mineral density after 24 month of use. Obstet Gynecol May 2004;103:899-906

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