Clinical Question: Should men avoid...

Clinical Question: Should men avoid drinking alcohol while taking sildenafil?

Setting: Other

reflection Design: Crossover trial (randomized)

Synopsis: Eight healthy literary institution [i]or[/i] seminary of learning students participated in this crossover trial. in succession separate occasions, each participant received, in a randomized manner, (1) sildenafil in a dose of 100 mg (2) r wine, (3) r wine and sildenafil, or (4) double placebo (i.e., a sugar pill and a nonalcoholic bottle of wine). When the combination was studied, each participant in the cluster drank one full bottle of wine above one hour, beginning one hour after the administration of sildenafil. Cardiac index, heart rate, and mean arterial hurry were determined every 15 minutes for three hours. The meditation design was somewhat artificial and may not have considered typical use, because the men were young and did not exercise or have intercourse following administration of the wine and/or sildenafil.

Sildenafil given alone reduc mean arterial hurry by 7 percent and peripheral vascular resistance on a maximum of 24 percent with no weight on heart rate or cardiac index. R wine increased heart rate on 27 percent and cardiac index by way of a maximum of 15 percent with an initial small (6 percent) rise in line pressure followed by a small (7 percent) fall. When given together, there was no difference in heart rate, mean arterial hurry cardiac index, or peripheral vascular resistance compared with alcohol given alone. This thought did not evaluate the validity of the wine on sexual function.

Bottom Line: Drinking alcohol following a dose of sildenafil has no more general intent on young men's cardiovascular parameters than alcohol alone. Although we ne to ways more research in more men--especially older men who are exercising--this preliminary information numbers us that we do not ne to caution men to avoid alcohol if they plan to take sildenafil. (Level of Evidence: 2b)

consideration Reference: Leslie SJ, et al. No adverse hemodynamic interaction between sildenafil and r wine. Clin Pharmacol Ther October 2004;76:365-70

Used with permission from Shaughnessy AF. Sildenafil does not interact with alcohol. Accessed online November 24 2004 at: http://www.InfoPOEMs.com.

COPYRIGHT 2005 American Academy of Family Physicians

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