Low-dose aspirin therapy is used ro...

Low-dose aspirin therapy is used routinely for the prevention of arterial thrombosis. somewhat old patients tend to have adverse reactions to aspirin, including renal results In high dosages, aspirin accompanys to increase uric acid excretion, while lower dosages may cause its retention. Aspirin therapy at the anti-inflammatory dosage of the same height has been shown to have a negative general intent on renal function in patients with renal insufficiency, cirrhosis, or heart disease. However, no studies had contemplateed at low-dose aspirin therapy and its impact forward the renal system. Segal and associates evaluated the tenors of low-dose aspirin therapy in succession renal function and uric acid in somewhat old patients.

Patients enlisted in the trial had been admitted to a long-term geriatric center To participate, they had to have been stable for at least brace weeks before the study began and from head to foot the study period. Patients were exclud if they had any medical condition or history that would place them at risk for adverse imports of aspirin therapy. They also were exclud if their creatinine on a level was higher than 1.6 mg by dL (140 mmol per L) or higher.

Participants in the consideration were placed on a controlled-protein diet undivided week before and during the studious mood A control group that was similar to the intervention clump also was assessed.Patients who participated in the consideration were given 100 mg of enteric-coated aspirin daily for sum of two units weeks. Blood and 24-hour urine samples were consider probableed before the first dose of aspirin and then weekly during the treatment and follow-up phase of the investigation Blood tests were performed, including measurement of vital fluid urea nitrogen (BUN), serum salicylate, creatinine, uric acid, and albumin evens The 24-hour urine test included creatinine and uric acid flushs A 24-hour creatinine clearance was calculated from the results

There were 83 patients in the active treatment arrange and 40 in the ascendency group. The average age was 81 years (range, 56 to 98).After sum of two units weeks of low-dose aspirin therapy, 72 percent of the patients had decreased urinary excretion of creatinine, and 45 percent had decreased uric acid excretion. In addition, mean creatinine horizontals and uric acid clearances decreased, while serum BUN creatinine, and uric acid horizontals increased significantly. When these patients were compared with the collection of patients who did not receive aspirin therapy, a significant deterioration in all horizontals was noted. At the extremity of the three-week follow-up period, 48 percent of patients who had received low-dose aspirin therapy had a persisted decline in creatinine clearance from baseline. This decline also was significant when this form into groups was compared with the mastery group.

The authors judge that short-term, low-dose aspirin therapy may have a significant adverse drift on renal function in somewhat old patients. They note that this negative consequence persisted for at least three weeks after aspirin therapy was discontinued. The authors add that equable though drug information sources and textbook do not commend monitoring renal function in somewhat old patients taking low-dose aspirin therapy, it appears that this therapy may have a negative result on renal function in this group

Segal R et al. Early and late imports of low-dose aspirin on renal function in somewhat old patients. Am J Med October 15 2003;115:462-6

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