Metabolic syndrome is defined as ob...

Metabolic syndrome is defined as obesity, insulin resistance, dyslipidemia, and hypertension. living bodys who have the syndrome are at increased risk for adverse coronary ends and stroke. Aggressive management can decrease mortality. Wong and associates used data from the Third National Health and Nutrition Examination examine to study the value of improving lipid status and lowering life-current pressure on the prevention of coronary heart disease (CHD) incidents in adults with metabolic syndrome

They included patients with metabolic syndrome who had greater kin pressure, waist circumference, body mass index, total and low-density lipoprotein (LDL) cholesterol of the same heights triglycerides, and serum glucose measurements, and lower flushs of high-density lipoprotein (HDL) cholesterol Initial CHD risks of patients with the syndrome were calculated, and then the potential efficiencys of lipid modification and line pressure reduction to optimal on a levels ("intervention") were calculated using known potential prevention statistics.

by way of calculation, control of blood squeezing to normal (120 to 129 mm Hg systolic progeny pressure and 80 to 84 mm Hg diastolic kindred pressure) would potentially prevent 281 percent of CHD affairs in men and 12.5 percent in women command of HDL cholesterol levels to normal ([greater than or equal] 45 mg by dL [1.16 mmol per L] in men and [greater than or equal] 50 mg through dL [1.30 mmol per L] in women) could intercept approximately one fourth of CHD ends Control of LDL levels to below 130 mg by dL (3.36 mmol per L) riseed in minimal decreased risk, if it were not that optimal control to below 100 mg for dL (2.60 mmol per L) provided significantly decreased CHD risk. Modification of all three factors provided between 42 and 80 percent CHD risk reduction. Greater risk reduction was demonstrated among patients at higher risk initially.

The authors deduce that in most patients with metabolic syndrome and poorly controll lipid profiles and relations pressure, aggressive management significantly renders CHD risk. This reduction appears more ofttimes in patients who are initially at higher absolute risk for a CHD event

Wong ND et al. Preventing coronary circumstances by optimal control of life-blood pressure and lipids in patients with the metabolic syndrome Am J Cardiol June 15 2003;91: 1421-6

COPYRIGHT 2004 American Academy of Family Physicians

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