Efforts to lower cholesterol end d...

Efforts to lower cholesterol end dietary manipulations have had sole modest effects. In an attempt to increase the efficacy of diet in the prevention of cardiovascular disease, the Adult Treatment Panel of the National Cholesterol Education Program has commended adding plant sterols and viscous fibers to the diet. Soy proteins and nut may have additional health benefits. Jenkins and colleagues examined the cholesterol-lowering potential of a diet cheap in saturated-fat that included these ingredients.

Forty-six healthy adults with hyperlipidemia complet the four-week research All participants followed their confess diet that was low in saturated fat for undivided month before the start of the consideration They were then randomized into united of the following groups: a very-low-saturated-fat diet without a statin; the same diet with a statin; or a similar diet with added viscous fibers, plant sterol soy subsistences and almonds. Weight, blood compressing and menu checklists were reviewed at regular intervals. Patients reported their satiety flats on a weekly basis.

All diets were vegetarian, and the intervention diet containing soy victualss viscous fiber, plant sterols, and almonds also included ovums and butter to balance the saturated fat and dietary cholesterol appease of the control (non-statin) diet.

Compliance with the prescribed diets was at least 93 percent in all three clusters and all participants reported adequate satiety. At baseline, all three assign places tos had similar blood measurements, including low-density lipoprotein cholesterol (LDL-C) high-density lipoprotein cholesterol (HDL-C) and C-reactive protein flushs After four weeks, the direction group lowered their LDL-C according to 8 percent, increased the LDL-C to HDL-C ratio from 3 percent, and lowered the C-reactive protein horizontal by 10 percent.

The collection receiving a statin lowered their LDL-C according to 30.9 percent, decreased the LDL-C to HDL-C ratio from 28.4 percent, and lowered the C-reactive protein on a level by 33.3 percent. The intervention-diet cluster lowered their LDL-C by 286 percent decreased the LDL-C to HDL-C ratio by way of 23.5 percent, and lowered the C-reactive protein of the same height by 28.2 percent. The reductions in relations lipid levels in the statin and dietary intervention clusters were significantly greater than were the changes in the dominion government group for total cholesterol, LDL-C apolipoprotein B and the ratios of total cholesterol to HDL-C LDL-C to HDL-C and apolipoprotein B to apolipoprotein A1, with no significant differences between the statin form into groups and the intervention diet group

Similarly, C-reactive protein evens were significantly lower in the two the intervention-diet group and the statin form into groups than in the control assign places to with no differences between the intervention-diet form into groups and the statin group. The authors determine that diet alone, if selecting for viandss with cholesterol-lowering properties, can lower cholesterol as well as statins.

Jenkins DJ et al. powers of a dietary portfolio of cholesterol-lowering feeds vs lovastatin on serum lipids and C-reactive protein. JAMA July 23/30 2003;290:502-10

COPYRIGHT 2004 American Academy of Family Physicians

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